| Customization: | Available |
|---|---|
| Function: | Vitamins and Minerals Deficiency Drug |
| Grade Standard: | Medicine Grade |
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| Product Name | Camptothecin |
| Latin Name | Camptotheca acuminata |
| Specification | 98%,99% |
| CAS.NO | 7689-03-4 |
| Mol. Formula | C20H16N2O4 |
| Appearance | Light Yellow Powder |
| Used Part | Seed |
| Test Method | HPLC |
| Extract Method | Ethanol |
| Grade | Pharmaceutical grade |
| Brand Name | Green yo |
| Package | Aluminum foil bag / Drum |
| Storage | Store in cool and dry places. Keep away from strong sunlight |
1.Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2.In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti- leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
1.Treatment Gastrointestinal cancer and leukemia.
2.Plant growth regulator activity and kill insects.
3.Treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.
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