| Customization: | Available |
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| CAS No.: | 19210-12-9 |
| Formula: | 19210-12-9 |
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Factory Price CAS 19210-12-9 Devil Claw Extract Harpagoside Harpagophytum Procumbens Extract
Latin Name: Harpagophytum procumbens
Specification:Harpagosides 1%~5%
Test Method: HPLC
Part of used:Root
Appearance: Brown fine powder
Devil's claw herb (Harpagophytum procumbens), is a plant widely used in South African traditional , specially by Bushmen, Hottentots and Bantu. Extracts of Devil's claw roots are widely used in Europe.
| TECHNICAL DATE SHEET | ||
| PRODUCT SPECIFICATIONS | ||
| Product Name: | Devil's Claw Extract | |
| Botanic Name: | Harpagophytum procumbens | |
| Part of plant | Root | |
| Solvent extraction | Water & ethanol | |
| Country of Origin: | China | |
| Excipent | 10% maltodextrin | |
| ANALYSIS ITEMS | SPECIFICATION | TEST METHOD |
| Appearance | Fine powder | Organoleptic |
| Color | Brown fine powder | Visual |
| Odour & Taste | Characteristic | Organoleptic |
| Identification | Identical to R.S. sample | HPTLC |
| Harpagosides | NLT 5.0% | UV |
| Sieve Analysis | 100% through 80 mesh | USP39 <786> |
| Loss on drying | ≤ 5.0% | Eur.Ph.9.0 [2.5.12] |
| Total Ash | ≤ 5.0% | Eur.Ph.9.0 [2.4.16] |
| Lead (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Mercury(Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Heavy metal | ≤ 10.0 mg/kg | Eur.Ph.9.0<2.4.8> |
| Solvents Residue | Conform Eur.ph. 9.0 <5,4 > and EC European Directive 2009/32 | Eur.Ph.9.0<2.4.24> |
| Pesticides Residues | Conform Regulations(EC) No.396/2005 including annexes and successive updates Reg.2008/839/CE | Gas Chromatography |
| Aerobic bacteria(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Yeast/Moulds(TAMC) | ≤100 cfu/g | USP39 <61> |
| Escherichia coli: | Absent in 1g | USP39 <62> |
| Salmonella spp: | Absent in 25g | USP39 <62> |
| Staphylococcus aureus: | Absent in 1g | |
| Listeria Monocytogenens | Absent in 25g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Packing | Pack in paper-drums and two plastic-bags inside N.W. 25 kgs I.D.35xH51cm. | |
| Storage | Store in a well-closed container away from moisture, light, oxygen. | |
| Shelf Life | 24 months under the conditions above and in its original packaging | |
Anti-inflammatory
A dried aqueous extract of devil's claw has been shown to exert a significant dose-dependent analgesic
and anti-inflammatory effect in rats at 5 and 10 mg/kg. However, carrageenan-induced paw edema was not affected by the isolated harpagoside constituent, suggesting harpagoside may not have an anti-inflammatory effect, at least in the doses used in this animal model of inflammation. This suggests that other devil's claw constituents may be responsible for the anti-inflammatory effect.
Analgesic
Harpagoside appears to exert a peripheral analgesic effect. Human research has demonstrated decreased pain in knee and hip osteoarthritis and nonspecific low-back pain after ingestion of devil's claw extracts containing harpagoside. Although the mechanism behind this effect has not yet been determined, it is thought to be closely connected to its anti-inflammatory properties.
Antioxidant
Animal research has demonstrated a significant antioxidant effect for devil's claw extract when administered intra-peritoneally to rats. Dose-dependent increases in superoxide dismutase, catalase, and glutathione peroxidase were observed in rat brain tissue and a reduction in lipid peroxidation was also noted. The antioxidant properties may be partially responsible for the anti-inflammatory effect of devil's claw extracts. The flavonoids (proven scavengers of free radicals) and plant phenols (hydrogen donors and oxygen radical neutralizers) present in devil's claw extracts may be the constituents responsible for the observed antioxidant activity.
Digestive Aid
The "bitter" action of devil's claw provided by the iridoid glycosides increases gastric acid production
and stimulates digestion.
Chondroprotective
Harpagophytum is chondroprotective, possibly due to inhibition of inflammatory mediators, including
COX-2, leukotrienes, nitric oxide, tumor necrosis factor-alpha (TNF-α), and interleukin-1β. In addition,
matrix metalloproteinases and elastase that play key roles in cartilage degradation are inhibited.
Harpagoside appears to exert a peripheral analgesic effect. Human research has demonstrated decreased pain in knee and hip osteoarthritis and nonspecific low-back pain after ingestion of devil's claw extracts containing harpagoside. Although the mechanism behind this effect has not yet been determined, it is thought to be closely connected to its anti-inflammatory properties.
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.| Shipping Terms | ||
| By Express | By Air | By Sea |
| Suitable for under 100kg Fast:3-4 days High cost Door to door service Easy to pick up the goods |
Suitable for more than 100kg Fast:3-4 days High cost Airport to airport Professional broker needed |
Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed |
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Q1. What's the MOQ?
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